21c Museum Hotel St Louis

Step into a world where art and history intersect at the 21c Museum Hotel St. Louis, a remarkable stop along Route 66. This vibrant hotel houses a contemporary art museum featuring stunning installations, making your stay not just a place to rest, but an immersive cultural experience. Located in a beautifully restored historic building, you’ll find chic accommodations and unique dining options that celebrate the essence of St. Louis. Whether you're exploring the creative exhibits or venturing out to discover the city, this hotel offers Route 66 travelers an unparalleled fusion of comfort and inspiration!