Grill on 21
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Grill on 21

Restaurant
208 S LaSalle St, Chicago, IL 60604, USA
(800) 774-2348 · Ext 19173, then #
www.grillon21.com

Nestled in the heart of Chicago along the iconic Route 66, Grill on 21 invites travelers to savor a unique blend of classic American fare and vibrant local flavors. With a warm, inviting atmosphere and an outdoor patio perfect for road-weary wanderers, this beloved eatery offers a culinary pit stop steeped in history. Indulge in mouthwatering dishes crafted from fresh ingredients, while soaking in the spirit of the Mother Road. Whether you're refueling for your next adventure or sharing stories with fellow travelers, Grill on 21 is an unforgettable stop on your journey.

Opening Hours
Monday6:30 – 10:30 AM, 11:00 AM – 2:30 PM, 5:00 – 10:00 PM
Tuesday6:30 – 10:30 AM, 11:00 AM – 2:30 PM, 5:00 – 10:00 PM
Wednesday6:30 – 10:30 AM, 11:00 AM – 2:30 PM, 5:00 – 10:00 PM
Thursday6:30 – 10:30 AM, 11:00 AM – 2:30 PM, 5:00 – 10:00 PM
Friday6:30 – 10:30 AM, 11:00 AM – 2:30 PM, 5:00 – 11:00 PM
Saturday7:00 AM – 2:30 PM, 5:00 – 11:00 PM
Sunday7:00 AM – 2:30 PM, 5:00 – 10:00 PM
Top Reviews
Jeffery Hurst

Jeffery Hurst

a month ago

"Service was impeccable!! Had the Lobster Bisque and the Del Monico Ribeye cooked Chicago Blue. Far and away the most flavorful and perfectly prepared ribeye I’ve experienced. Went with the truffle butter on the side which was very good but found the steak needed nothing. Fork tender and melted into my tastebuds. The Lobster Bisque was an experience in itself that left me craving another bite."

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Kay Kucz

Kay Kucz

a month ago

"A true HIDDEN GEM tucked inside the LaSalle Hotel! From the moment we walked in, the experience was nothing short of exceptional. Every single staff member played a role in making the evening feel special—from the person who greeted us and kept our bread warm and water glasses filled, to the team seamlessly clearing and resetting the table with perfect timing. Nothing was rushed, nothing was overlooked. We started with the lollipop lamb chops—four generous, perfectly cooked pieces that were absolutely delicious. For dinner, the Delmonico ribeye was outstanding, served with mushrooms and potato purée (mashed potatoes). A standout touch: the steak comes with a half head of roasted garlic to mix into the potatoes, along with two different specialty salts that elevated every bite. The smoked Old Fashioned is an absolute must. It had the perfect balance of smoke and flavor—hands down one of the best we’ve had. Our server, Eric, was phenomenal. Every recommendation he made was spot on, and his attention to detail truly enhanced our experience. The managers were also present throughout the evening, checking in with guests and making sure everything was flawless. As we were leaving for a play, a three-piece quartet was setting up for live music, adding yet another layer to the already fantastic atmosphere. Exceptional food, impeccable service at every level, and a warm, polished ambiance—this place sets the standard and is a definite must-return."

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BrownGirl Styles

BrownGirl Styles

a month ago

"Had an absolutely wonderful time here for dinner! The Truffle Risotto was one of the best I’ve ever tried. The service was great from the checkin to our server to the management coming up to thank us! Would 100% return!"

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Murugs Lingaswamy

Murugs Lingaswamy

2 months ago

"Went out for a group dinner from an event. Ambience was very nice. Predetermined menu and they served crab cake and salad it was great. Ordered Salmon for main course and drinks were little expensive but is expected being in the center of city on a nice 21st floor with great ambience."

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Grill on 21 | Route 66 Restaurant in Chicago, Illinois