WISEGUYS Italian
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WISEGUYS Italian

Restaurant
612 S Main St, Joplin, MO 64801, USA
(800) 774-2348 · Ext 13038, then #
order.toasttab.com/online/wiseguys-612-s-main-street

Nestled along the legendary Route 66 in Joplin, Missouri, WISEGUYS Italian invites travelers to savor authentic, homemade cuisine steeped in family tradition. This cozy eatery boasts a welcoming atmosphere perfect for weary road trippers looking to relax and refuel. With a 4.4-star rating from hundreds of satisfied guests, every dish—from hearty pastas to delectable pizzas—tells a story of passion and flavor that captures the spirit of the Mother Road. Don’t miss the chance to indulge in a slice of Italian heritage while journeying through history!

Opening Hours
Monday11:00 AM – 2:30 PM, 4:30 – 8:30 PM
Tuesday11:00 AM – 2:30 PM, 4:30 – 8:30 PM
Wednesday11:00 AM – 2:30 PM, 4:30 – 8:30 PM
Thursday11:00 AM – 2:30 PM, 4:30 – 8:30 PM
Friday11:00 AM – 9:00 PM
Saturday11:00 AM – 9:00 PM
SundayClosed
Top Reviews
Glenda Pargman

Glenda Pargman

5 months ago

"We goggled Italian in Joplin and gave it a try. It was a great meal. Met friendly customers who regularly eat here. Staff was amazing. We will be back and tell our friends who visit Joplin to give it a try!!"

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George Sims

George Sims

3 months ago

"WISEGUYS Italian WISEGUYS Italian delivers a satisfying and authentic Italian dining experience with a casual, laid-back vibe. Their menu features classic Italian dishes like hearty pasta, flavorful sauces, and well-seasoned meats. Portions are generous, and the quality of ingredients shines through. The atmosphere is cozy and inviting, making it a great spot for family dinners or casual outings. Service is attentive and friendly. A solid choice for those craving comforting Italian favorites."

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Fox Butler

Fox Butler

a month ago

"This is one of those hole-in-the-wall spots you hope never changes. The food was amazing and exceeded every expectation, and the service was outstanding from start to finish. Friendly, fast, and made you feel right at home. Easily one of the best Italian spots in Joplin."

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Erin Kirchner

Erin Kirchner

4 months ago

"Our first time here and we learned the owner makes homemade food passed down from his grandma, the bread is from a local bakery across the street, nothing tasted canned or frozen, it was made with pride and fresh to order. The food was so delicious, the atmosphere needs a little work but from my understanding they just switched locations and they were working out kinks. We will absolutely be coming here again and again!"

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WISEGUYS Italian | Route 66 Restaurant in Joplin, Missouri